Perimenopause and menopause · Prescription only · Clinician decides

For the 3 a.m. sweats and the nights you can't sleep.

Estradiol is the main estrogen your body makes less of in perimenopause and menopause. Here it comes as a skin patch or a daily gel. A licensed clinician decides whether hormone therapy is right for you, and adds progesterone or a vaginal cream when you need them.

From $124.12/moFor an estradiol patch. Your price depends on what your clinician prescribes.

  • $0 unless prescribed
  • Free shipping in a plain box
See the Direct Wellness Promise

Who it may be for

  • Women in perimenopause or menopause with hot flashes, night sweats, poor sleep, mood changes, or brain fog.
  • Women with vaginal dryness or pain with sex, who may add a low-dose vaginal estradiol cream.
  • Women already on hormone therapy who want a clinician to continue or adjust it.

People often ask about it for hot flashes or night sweats, poor sleep, mood swings, brain fog and vaginal dryness. These are reasons people ask, not promises of results.

How it works here

01 · Tell us what is going on

A short secure intake covers your health history, medications, and goals. Nothing is prescribed from the form alone.

02 · A licensed clinician reviews

Your clinician decides whether this is safe and appropriate for you, orders labs when they are needed, and may ask for a video visit.

03 · Ships to your door if prescribed

A licensed pharmacy prepares it and ships it to you. You see the full price, including any visit or lab fee, before you pay.

What to know first

  • If you still have a uterus, estradiol is paired with progesterone, because estrogen on its own raises the risk of cancer of the uterine lining.
  • Estrogen medicines carry a boxed warning about endometrial cancer, heart disease, stroke, blood clots, breast cancer, and dementia. Your clinician uses the lowest dose that helps and reviews it with you over time.
  • Hormone therapy is not for anyone with unexplained vaginal bleeding, a current estrogen-sensitive cancer such as breast cancer, a recent blood clot, or uncontrolled high blood pressure. The intake asks about each of these.
  • Common effects are breast tenderness, spotting, headache, and bloating. A patch can irritate the skin where it sits. Progesterone can make you drowsy, so it is taken at bedtime.
  • Tell your clinician if you smoke or get migraines with aura, because both raise the risk of blood clots.

Common questions

Patch or gel?

Both deliver estradiol through the skin. Some people like a patch they do not think about every day, and others prefer a gel. If adhesives bother your skin, the gel is the usual choice. Your clinician helps you decide.

Do I need progesterone?

If you still have a uterus, usually yes, because it protects the lining of the uterus. After a hysterectomy you usually do not. Your clinician decides, and chooses 100 or 200 mg.

What is the vaginal cream for?

A low-dose estradiol cream treats dryness, irritation, and pain with sex. It is added to a patch or gel plan.

I already take hormones. Can I switch?

Yes. The intake asks what you take now and at what dose, so your clinician can continue a similar dose or adjust it. Estradiol tablets and compounded creams are not offered here.

What if the clinician decides it is not right for me?

Then you will not be charged for medication. See our refund policy for the full terms.

Other options a clinician may consider

See all treatments →

Your clinician decides what is safe for you. You see the full price before you pay anything.

Start my visit →